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METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP)
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DeCS
Descriptor
English
:
Methylenetetrahydrofolate Dehydrogenase (NADP)
Descriptor
Spanish
:
Metilenotetrahidrofolato Deshidrogenasa (NADP)
Descriptor
Portuguese
:
Metilenotetra-Hidrofolato Desidrogenase (NADP)
Synonyms
English
:
Methylenetetrahydrofolate Dehydrogenase (NADP+)
Tree Number:
D08.811.682.662.253
Definition
English
:
An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher
eukaryotes
a trifunctional enzyme exists with additional
METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE
and
FORMATE-TETRAHYDROFOLATE LIGASE
activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of
HOMOCYSTEINE
to
METHIONINE
via
METHIONINE
SYNTHETASE.
Indexing Annotation
English
:
do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+)
See Related
English
:
Formate-Tetrahydrofolate Ligase
Methenyltetrahydrofolate Cyclohydrolase
History Note
English
:
2004(1975);
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
8940
Unique Identifier:
D008754
Occurrence in VHL
:
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